(eng): This book contains the proceedings of the International Conference on Bioinformatics Mo- dels, Methods and Algorithms (BIOINFORMATICS 2012). The purpose of the International Conference on Bioinformatics Models, Methods and Al- gorithms is to bring together researchers and practitioners interested in the application of computational systems and information technologies to the field of molecular biology, inclu- ding for example the use of statistics and algorithms to understanding biological processes and systems, with a focus on new developments in genome bioinformatics and computati- onal biology. Areas of interest for this community include sequence analysis, biostatistics, image analysis, scientific data management and data mining, machine learning, pattern re- cognition, computational evolutionary biology, computational genomics and other related fields. BIOINFORMATICS is integrated in BIOSTEC (International Joint Conference on Biomedi- cal Engineering Systems and Technologies).